Funded through the Palliative Care Clinical Studies Collaborative (PaCCSC), this pragmatic, phase III, multi-site, double-blind, placebo controlled, parallel arm, dose increment randomised trial of regular, low dose extended release morphine for chronic refractory breathlessness is being conducted at Calvary Public Hospital Bruce and Calvary Health Care Kogarah and previously at Calvary Mater Newcastle. The study aims to enhance the evidence base for the pharmacological treatment of chronic refractory breathlessness using potential therapies compared to placebo.